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This regional operational guide on comprehensive sexuality education (CSE) is intended to help UNFPA personnel in the Arab Region and their CSE implementing partners to better understand and use opportunities to advance CSE in national policies and accountability mechanisms, and to provide UNFPA Country Offices and counterparts with concrete and concise guidance on recommended approaches and possible entry points to plan and lead effective CSE programs in the Region. This operational guide also offers justifications to advocate for favourable policy environments and increased investments in CSE at the Regional level.